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Product Details:
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| Name: | Trilostane | Cas: | 13647-35-3 |
|---|---|---|---|
| Mf: | C20H27NO3 | Purity: | 99% |
| Appearance: | White Powder | Package: | 1kg/bag Or 25kgs/drum |
| High Light: | Anti Estrogen Api Raw Steroid Powder,Trilostan Raw Steroid Powder,CAS 13647-35-3 Raw Hormone Powder |
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| Product name | Trilostane |
| CAS No | 13647-35-3 |
| Molecular formula | C20H27NO3 |
| Molecular Weight | 289.3495 |
| Amino Acid Composition: | 10% of theoretical |
| Type: | Powder |
| Apperance: | white powder |
| Assay | 99% |
| MOQ | 10G |
Description
Trilostane can suppress cortical hormone synthesis process of 3 beta dehydrogenase, make cortisol, aldosterone synthesis reduce, clinical used in the treatment of Cushing syndrome(cortisol increase disease) and primary aldosteronism,the effect is not good than metyrapone. This product has significantly reduced blood level role, may relevant to its inhibit synthetic.
Application
Trilostane is used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible.
Trilostane blocks an enzyme involved in the production of several steroids including cortisol. Inhibiting this enzyme inhibits the production of cortisol. In Cushing's syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions of the body, too much can cause problems. Trilostane reduces the amount of steroids produced by the adrenal gland.
Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5,4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.
Side effect:Symptoms of overdose include darkening of skin, drowsiness or tiredness, loss of appetite, mental depression, skin rash, and/or vomiting.
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